Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?우한-Hu-1 변종에서 XD 및 XE 변종까지: SARS-CoV-2 스파이크 단백질을 표적으로 하는 것이 여전히 COVID-19에 대한 약학적으로 적절한 옵션입니까?Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 변종, [키워드] contributing to COVID-19 COVID-19 pandemic death Efficacy feature glycoprotein hospitalisations infections milestone MPro Mutation mutations outbreak pandemic Paxlovid Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant spike Spike protein Surface glycoprotein the SARS-CoV-2 the SARS-CoV-2 genome the Spike Treatment Vaccines variant viral surface Wuhan-Hu-1 XD variant XE variant. [DOI] 10.1080/14756366.2022.2081847 PMC 바로가기 [Article Type] Article
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Maternal SARS-CoV-2 sero-surveillance using newborn dried blood spot (DBS) screening specimens highlights extent of low vaccine uptake in pregnant womenArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Adults analyzed Antibody concentrations Antibody neutralization Blood complications contributing to COVID COVID-19 delta variant dose Dried blood spots fetal General population help highlight Hospital admissions Immunity IMPROVE information Intervention Maternal MONITOR natural infection Newborn newborn screening omicron outcomes pregnant women proportion reduction in representing Result SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies serostatus specimen the SARS-CoV-2 the vaccine utility vaccination vaccination. Vaccine women [DOI] 10.1080/21645515.2022.2089498 PMC 바로가기
Investigating public awareness, prevailing attitudes and perceptions towards domestic violence and abuse in the United Kingdom: a qualitative studyArticle Published on 2022-11-082022-11-15 Journal: BMC Public Health [Category] 치료제, [키워드] Abuse analysed Analysis Care children Community community setting concerning conducted contributing to COVID-19 COVID-19 pandemic detect develop domestic violence effective effective interventions event Factor Health help highlighting Impact instance Intervention interventions investigated lockdowns mechanism media Raising awareness Rapid Rapid screening tools. reduce Research rising Support targeted intervention Topic transcribed understanding Violence [DOI] 10.1186/s12889-022-14426-9 PMC 바로가기
Differences in environmental stability among SARS-CoV-2 variants of concern: both omicron BA.1 and BA.2 have higher stabilityArticle Published on 2022-11-012022-11-16 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] Beta calculated Characteristics Concentration contributing to Delta difference Disinfection Disinfection effectiveness Effectiveness Efficacy environmental stability evaluate evaluated Ex vivo exhibited Gamma in vitro inactivated Infection median omicron regression analysis risk SARS-CoV-2 SARS-CoV-2 variant Spread stability survival transmissibility of SARS-CoV-2 Transmission variant variants variants of concern virus Virus survival. virus titre VoC VOCs was determined were measured Wuhan Wuhan strain [DOI] 10.1016/j.cmi.2022.05.020 PMC 바로가기
Central Retinal Vein Occlusion After Discontinuation of Rivaroxaban Therapy in a Young Patient with COVID-19 Pulmonary Embolism: A Case ReportArticle Published on 2022-11-012022-11-15 Journal: The American journal of case reports [Category] 진단, [키워드] anticoagulation Combination common contributing to Convalescent plasma therapy Course COVID-19 decrease Dexamethasone diagnosed discharge edema Factor healthy Hospitalized hypercoagulability initiated intravitreal injection knowledge occurred Oxygen therapy Patient Prophylactic pulmonary rebound Remdesivir report retinal vein retinal vein occlusion rivaroxaban Severe COVID-19 pneumonia significantly subsegmental the patient therapeutic therapy treated Treatment visual acuity was performed were excluded with COVID-19 [DOI] 10.12659/AJCR.937739 PMC 바로가기
Care of the Seriously Ill Patient with SARS-CoV-2Article Published on 2022-11-012022-11-16 Journal: The Medical clinics of North America [Category] SARS, 변종, [키워드] caused contributing to COVID-19 COVID-19 pandemic Critical care effective vaccine examined Health Ill knowledge medication pandemic Patient SARS-CoV-2 translational Treatment. variant [DOI] 10.1016/j.mcna.2022.08.002 PMC 바로가기
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severityReview article Published on 2022-11-012022-10-05 Journal: Gene [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE1 ACE2 AGTR1 ApoE association Case-control CCR5 Clinical outcome contribute contributing to Control correlation country COVID-19 COVID-19 pandemic COVID-19 susceptibility Critical eligible Evidence exacerbated examined Factor Genes Genetic genetic determinant Genetic polymorphism Genetic variant greater Health Healthcare system Host host genetics human gene I/D identify IFITM3 implicated increased risk increasingly infected individual infected individuals Infection investigated magnitude manifestation Manifestations Meta-analysis meta-analysis mutations Patient performed polymorphism progression provide required Research rs2285666 SARS-CoV-2 severe COVID-19 severity Statistical power statistically significant susceptibility systematic review variant with COVID-19 [DOI] 10.1016/j.gene.2022.146790 [Article Type] Review article
Temporal changes in the accessory protein mutations of SARS-CoV-2 variants and their predicted structural and functional effectsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] accessory protein accessory proteins Affect amino acid sequence association bioinformatics candidate changes in contributing to correlation COVID-19 determine domains Effect Factor Frequency functional humans identify Infection Mutation mutations mutations. occur ORF6 ORF8 predicted Protein PROVEAN Q57H SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence spike Spread Temporal variant variants of concern was used [DOI] 10.1002/jmv.27964 PMC 바로가기